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I'm using Ktistec theming hooks to make it easier to spot posts from actors I enjoy reading, to identify posts that are part of conversations I'm in, to identify posts about topics I'm interested in, and to simply expose more information visually.
The hashtags I follow don't require much emphasis, but I want them to stand out a little, so I theme these posts with a bold left border.

It's helpful when I can spot posts that are parts of conversations I'm in, so my theme styles my replies, and others' replies to me. In the latter case, it also differentiates between cases where I'm one of the actors mentioned vs. cases where I'm the only actor mentioned.

There are a handful of people I follow who regularly post about topics I love. I've created custom backgrounds for posts from these authors.

(This is also my #FollowFriday post. 😀 If you're not into my theming, but want to see amazing photos of abandoned places around the world and sometimes sleeping seals, follow @ObsidianUrbex. If you love physics, math, music, and related topics, or want to love physics, math, music, and related topics, follow @johncarlosbaez.)
All of this is powered by extensive post metadata that was recently added and is surfaced in classes and data attributes. You can, for example, customize a theme based on actor or object type, object status (sensitive, has replies, etc.), visibility, relationship state (followed by me, mentions me, etc.), the creator/sharer handle, etc. Details are in the theming documentation.